weak D type 2.1



Key changes from standard allele

1154G>C (G385A)
301T>A (F101I)

ISBT allele designation

RHD*weak D type 2.1

Nucleotide changes relative to "standard RHD"

c.[301 T>A;1154 G>C]

Amino acid changes relative to standard protein

F101I, G385A

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Haplotype (typical)


Allele cluster

Eurasian D cluster


First submission to GenBank: 2009 FN568100 (submitted 2009-11-11, released 2009-11-16)




Linz region: FN568100
France (general): Not detected among 257 weak D type 2-like samples Raud L et. al. Transfus Med. 2017 Nov 22. doi: 10.1111/tme.12485.

Additional comments

Weak D type 2.1 is similar to weak D type 2 in respect to the G385A mutation and will be mistyped as weak D type 2, if the F101I polymorphism is not checked.
The F101I substitution is conservative but expected to be in the extracellular part of RhD. A possible loss of D epitopes incurred by that mutation has not been investigated yet.

Last update: 2017-12-05 (yyyy-MM-dd)