RHD*weak D type 2.1
c.[301 T>A;1154 G>C]
weak D type; weakened D expression
Eurasian D cluster
First submission to GenBank: 2009 FN568100 (submitted 2009-11-11, released 2009-11-16)
Linz region: FN568100
France (general): Not detected among 257 weak D type 2-like samples Raud L et. al. Transfus Med. 2017 Nov 22. doi: 10.1111/tme.12485.
Weak D type 2.1 is similar to weak D type 2 in respect to the G385A mutation and will be mistyped as weak D type 2, if the F101I polymorphism is not checked.
The F101I substitution is conservative but expected to be in the extracellular part of RhD. A possible loss of D epitopes incurred by that mutation has not been investigated yet.
Last update: 2017-12-05 (yyyy-MM-dd)