DOL-2

Structure

RHD(M170T,F223V,L378V)

Key changes from standard allele

1132C>G (L378V)
509T>C (M170T)
667T>G (F223V)

ISBT allele designation

RHD*12.02
RHD*DOL2

Nucleotide changes relative to "standard RHD"

c.[509 T>C;667 T>G;1132 C>G]

Amino acid changes relative to standard protein

M170T, F223V, L378V

Haplotype (typical)

not reported

Usually linked to ceBI

Allele cluster

weak D type 4 cluster

Descriptions

First submission to GenBank: 2005 AM072761 (submitted 2005-08-08, released 2005-11-15)

First full publication: 2009 Flegel WA et. al. Transfusion. 2009 Jun;49(6):1059-69. Epub 2009 Feb 25.

Other relevant descriptions:
DOL-2 is linked to ceBI Roussel M et. al. Transfusion. 2012 Jun 13. aheadofprint

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Anti-D observed Roussel M et. al. Transfusion. 2012 Jun 13. aheadofprint

Observations

African ancestry (general): Roussel M et. al. Transfusion. 2012 Jun 13. aheadofprint
Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
French of African ancestry: 1 of 280 D pos donors; linked to RHCE*ceBI Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013

Additional comments

This allele has been published shortly after DOL-3 that was initially not given an allele name. The non-sequential numbering is kept to avoid confusion.

Last update: 2018-04-23 (yyyy-MM-dd)